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M9490675.TXT
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1994-09-24
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Document 0675
DOCN M9490675
TI Neuroimaging and neuropathologic findings in AIDS patient with
cytomegalovirus infection.
DT 9411
AU Nagamitsu S; Okabayashi S; Dai S; Morimitsu Y; Murakami T; Matsuishi T;
Motizuki M; Kato H; Department of Pediatrics and Child Health, Kurume
University; School of Medicine.
SO Intern Med. 1994 Mar;33(3):158-62. Unique Identifier : AIDSLINE
MED/94339563
AB This 21-year-old male with hemophilia A developed cytomegalovirus (CMV)
retinitis associated with acquired immunodeficiency syndrome (AIDS). He
had a history of numerous blood transfusions. Serum antibody titers
became positive for human immunodeficiency virus (HIV), when the patient
was 18 years of age. Three years later, he developed CMV retinitis due
to his immunosuppression. Ganciclovir (DENOSINE, TANABE SEIYAKU CO.,
LTD., Osaka, Japan) therapy given for 4 weeks produced a marked
improvement in the ocular fundal findings, but the neurologic signs and
symptoms, including headache, hypoesthesia, disorientation, and dementia
became worse. T2-weighted magnetic resonance imaging (MRI) demonstrated
a diffuse high intensity area in the periventricular white matter and
small focal or patchy lesions in the hippocampus, basal ganglia,
midbrain, medulla oblongata and the nucleus dentatus. The patient died
of HIV encephalopathy and CMV infection. Characteristic CMV intranuclear
inclusion bodies were observed histologically in most sites of the brain
including the hippocampus, white matter, basal ganglia, midbrain,
medulla oblongata, nucleus dentatus and the retina. Infiltration by
monocyte-macrophage and multinucleated giant cells, which are
characteristic of HIV encephalopathy, were observed in the
periventricular white matter and the hippocampus. In this patient, the
neuroimaging findings were compatible with the neuropathologic
observations. MR imaging proved useful in detecting the central nervous
system (CNS) lesions of AIDS and CMV infection.
DE Adult AIDS Dementia Complex/*COMPLICATIONS/*PATHOLOGY/RADIOGRAPHY Case
Report Cytomegalovirus Retinitis/*COMPLICATIONS/*PATHOLOGY
Hemophilia/COMPLICATIONS Human Inappropriate ADH
Syndrome/COMPLICATIONS Magnetic Resonance Imaging Male Tomography,
X-Ray Computed JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).